Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor.

ID: ALA1134228

Journal: Bioorg Med Chem Lett

Title: Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor.

Authors: Darker JG, Porter RA, Eggleston DS, Smart D, Brough SJ, Sabido-David C, Jerman JC.

Abstract: Truncated peptide analogues of orexin-A were prepared and their biological activity assesed at the orexin-1 receptor. Progressive N-terminal deletions identified the minimum C-terminal sequence required for maintaining a significant agonist effect, whilst an alanine scan and other pertinent substitutions identified key side-chain and stereochemical requirements for receptor activation.

CiteXplore: 11266181

DOI: 10.1016/s0960-894x(01)00043-9

Patent ID: ┄