HIV Rev peptides conjugated with peptide nucleic acids and their efficient binding to RRE RNA.

ID: ALA1134253

Journal: Bioorg Med Chem Lett

Title: HIV Rev peptides conjugated with peptide nucleic acids and their efficient binding to RRE RNA.

Authors: Kumagai I, Takahashi T, Hamasaki K, Ueno A, Mihara H.

Abstract: HIV Rev peptides conjugated with peptide nucleic acids (PNAs) were designed and synthesized to develop a designing approach for a novel RNA-binding molecule. The binding affinities of PNA-peptides with the Rev responsive element (RRE) RNA were determined by the competition assay using a rhodamine-labeled Rev. The peptide conjugated with an antisense PNA (TGCGC) bound RRE RNA more efficiently than the molecule without the PNA or the peptide sequence.

CiteXplore: 11354369

DOI: 10.1016/s0960-894x(01)00169-x

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