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ID: ALA1134254
Journal: Bioorg Med Chem Lett
Title: Syntheses of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity.
Authors: Nam NH, You YJ, Kim Y, Hong DH, Kim HM, Ahn BZ.
Abstract: A series of 3-aryl-2-propenoates including cinnamates, (E)-methyl/ethyl 3-[2-(1,4-dimethoxy-5,8-dione)naphthalenyl]-2-propenoates (8ba, 8bb) and (E)-methyl/ethyl 3-[2-(1,4-dihydroxy-9,10-dione)anthracenyl]-2-propenoates (9aa,9ab) was synthesized and evaluated for antitumor cytotoxicity. It was found that the ortho- or para-dihydroxy funtionality on the aryl ring was essential for the cytotoxicity of cinnamates. Compounds 8ba, 8bb and 9aa, 9ab showed potent cytotoxicity against various tumor cell lines.
CiteXplore: 11354370