Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions.
Basic Information
ID: ALA1134418
Journal: Bioorg Med Chem Lett
Title: Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions.
Authors: Kaneko M, Nakashima T, Uosaki Y, Hara M, Ikeda S, Kanda Y.
Abstract: Tetrocarcin A was recently identified as an inhibitor of the anti-apoptotic function of Bcl-2. We synthesized novel tetrocarcin derivatives in order to increase their selective inhibitory activity against Bcl-2. It was found that 21-acetoxy-9-glycosyloxy derivatives had potent Bcl-2 inhibitory activity without significant antimicrobial activity.
CiteXplore: 11294384
DOI: 10.1016/s0960-894x(01)00094-4
Patent ID: ┄
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