Document Report Card

ID: ALA1134618

Journal: J Med Chem

Title: Synthesis and biological evaluation of sialylmimetics as rotavirus inhibitors.

Authors: Fazli A, Bradley SJ, Kiefel MJ, Jolly C, Holmes IH, von Itzstein M.

Abstract: Rotaviruses cause severe gastroenteritis in infants and are estimated to be responsible for over 600 000 deaths annually, primarily in developing countries. The development of potential inhibitors of this virus is therefore of great interest, particularly since the safety and efficacy of rotaviral vaccines has recently been questioned. This study describes the synthesis of a variety of compounds that can be considered as mimetics of N-acetylneuraminic acid thioglycosides and the subsequent in vitro biological evaluation of these sialylmimetics as inhibitors of rotaviral infection. Our results show that readily accessible carbohydrate-based compounds have the potential to act as inhibitors of rotaviral replication in vitro, presumably through inhibition of the rotaviral adhesion process.

CiteXplore: 11563928

DOI: 10.1021/jm0100887