Document Report Card

ID: ALA1134671

Journal: J Med Chem

Title: Novel lead generation through hypothetical pharmacophore three-dimensional database searching: discovery of isoflavonoids as nonsteroidal inhibitors of rat 5 alpha-reductase.

Authors: Chen GS, Chang CS, Kan WM, Chang CL, Wang KC, Chern JW.

Abstract: A hypothetical pharmacophore of 5 alpha-reductase inhibitors was generated and served as a template in virtual screening. When the pharmacophore was used, eight isoflavone derivatives were characterized as novel potential nonsteroidal inhibitors of rat 5 alpha-reductase. This investigation has demonstrated a practical approach toward the development of lead compounds through a hypothetic pharmacophore via three-dimensional database searching.

CiteXplore: 11689062

DOI: 10.1021/jm010433s