Document Report Card
Basic Information
ID: ALA1134700
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and characterisation of a peptide with oxaloacetate decarboxylase activity.
Authors: Taylor SE, Rutherford TJ, Allemann RK.
Abstract: The synthesis of Oxaldie-3, a synthetic 31-residue peptide with oxaloacetate decarboxylase activity, is described. Biophysical characterisation by gel filtration, CD and NMR spectroscopy indicated that the peptide adopted a folded structure in solution. Oxaldie-3 was an efficient catalyst at concentrations as low as 2 microM, 100-fold lower than the previously described Oxaldie-2, which relied on aggregating alpha-helices for activity. Oxaldie-3 speeded decarboxylation by more than three orders of magnitude relative to simple amines.
CiteXplore: 11551766