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ID: ALA1134702

Journal: Bioorg Med Chem Lett

Title: Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor.

Authors: Sing WT, Lee CL, Yeo SL, Lim SP, Sim MM.

Abstract: Arylalkylidene rhodanines 2(a-d) inhibit HCV NS3 protease at moderate concentrations. They are better inhibitors of other serine proteases such as chymotrypsin and plasmin. However, the selectivity of arylmethyliden e rhodanines (8a, 9a) with bulkier and more hydrophobic functional groups increases by 13- and 25-fold towards HCV NS3 protease respectively.

CiteXplore: 11206478

DOI: 10.1016/s0960-894x(00)00610-7