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ID: ALA1134704
Journal: Bioorg Med Chem Lett
Title: Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors.
Authors: Su T, Wu Y, Doughan B, Jia ZJ, Woolfrey J, Huang B, Wong P, Park G, Sinha U, Scarborough RM, Zhu BY.
Abstract: A series of potent and selective factor Xa inhibitors was synthesized using various readily available amino acids as central templates. The most potent compound displays IC(50) of 3 nM.
CiteXplore: 11677132