Selective, orally active MMP inhibitors with an aryl backbone.

ID: ALA1134722

Journal: Bioorg Med Chem Lett

Title: Selective, orally active MMP inhibitors with an aryl backbone.

Authors: Barta TE, Becker DP, Bedell LJ, De Crescenzo GA, McDonald JJ, Mehta P, Munie GE, Villamil CI.

Abstract: This letter describes SAR exploration and rat PK optimization of a series of novel, MMP-1 sparing aryl hydroxamate sulfonamides with activity against MMP-2 and MMP-13.

CiteXplore: 11549451

DOI: 10.1016/s0960-894x(01)00487-5

Patent ID: ┄