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ID: ALA1134741
Journal: Bioorg Med Chem Lett
Title: Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation.
Authors: da Silva AJM, Melo PA, Silva NM, Brito FV, Buarque CD, de Souza DV, Rodrigues VP, Poças ES, Noël F, Albuquerque EX, Costa PR.
Abstract: Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity. The most potent compound (2b, IC50 = 1 microM) was selected for study of its pharmacological profile.
CiteXplore: 11212092