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ID: ALA1134742
Journal: Bioorg Med Chem Lett
Title: Synthesis and structure-activity relationships of thiotetronic acid analogues of thiolactomycin.
Authors: Sakya SM, Suarez-Contreras M, Dirlam JP, O'Connell TN, Hayashi SF, Santoro SL, Kamicker BJ, George DM, Ziegler CB.
Abstract: 3-Acetyl analogues of thiolactomycin, a thiotetronic acid natural product, were synthesized and profiled against livestock pathogens. Some analogues showed improved activity over thiolactomycin against Staphylococcus aureus and comparable activity against Pasteurella multocida. Several semisynthetically modified analogues of thiolactomycin showed no improvement in activity over thiolactomycin.
CiteXplore: 11591516