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ID: ALA1134750
Journal: Bioorg Med Chem Lett
Title: Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry.
Authors: Juteau H, Gareau Y, Labelle M, Lamontagne S, Tremblay N, Carrière MC, Sawyer N, Denis D, Metters KM.
Abstract: Potent and selective EP3 receptor ligands were found by making a library using solid-support chemistry. These compounds can be obtained by a Suzuki coupling reaction of a solid-supported benzyl bromide using various boronic acids. The yields obtained for this reaction were in the range of 24-95% of arylmethyl cinnamic acid 1 after cleavage from the Wang resin.
CiteXplore: 11266183