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ID: ALA1134806
Journal: Bioorg Med Chem Lett
Title: Parallel solid-phase synthesis of nucleoside phosphoramidate libraries.
Authors: Jin Y, Chen X, Côté M, Roland A, Korba B, Mounir S, Iyer RP.
Abstract: Combinatorial chemistry is playing an increasingly prominent role in the process of drug discovery. A nucleic acid-based (NAB) scaffold can be engineered to create functional group and topological diversity in a library. Described herein is the parallel solid-phase synthesis of combinatorial libraries of nucleoside phosphoramidates, and the first evaluation of antiviral activity against hepatitis B virus (HBV).
CiteXplore: 11514138