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ID: ALA1134809
Journal: Bioorg Med Chem Lett
Title: Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors.
Authors: Dener JM, Wang VR, Rice KD, Gangloff AR, Kuo EY, Newcomb WS, Putnam D, Wong M.
Abstract: Truncation of potent and selective dibasic inhibitors afforded monocharged inhibitors of human mast-cell tryptase. Using two classes of analogues as lead structures, several monocharged derivatives were identified with K(i) values ranging from 0.084 to 0.21 microM against the enzyme.
CiteXplore: 11527724