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ID: ALA1134810
Journal: Bioorg Med Chem Lett
Title: G-quadruplex DNA binding by a series of carbocyanine dyes.
Authors: Kerwin SM, Sun D, Kern JT, Rangan A, Thomas PW.
Abstract: We have examined a number of carbocyanine dyes for their ability to bind intramolecular G-quadruplex DNA structures (G4'-DNA) using a Taq polymerase stop assay. Of the five dyes examined, only one, N,N'-diethylthiacarbocyanine iodide (DTC), was found to bind to G4'-DNA. DTC was also the only dye found to inhibit human telomerase at 50 microM concentration.
CiteXplore: 11549435