Basic Information
ID: ALA1134828
Journal: Bioorg Med Chem Lett
Title: The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin.
Authors: Murray PJ, Kranz M, Ladlow M, Taylor S, Berst F, Holmes AB, Keavey KN, Jaxa-Chamiec A, Seale PW, Stead P, Upton RJ, Croft SL, Clegg W, Elsegood MR.
Abstract: A novel synthetic strategy is described which may be used to prepare analogues of the antimalarial, fungal metabolite apicidin. Compared to the natural product, one analogue shows potent and selective activity in vitro against the parasite Trypanosoma brucei and low mammalian cell toxicity.
CiteXplore: 11277517
DOI: 10.1016/s0960-894x(01)00049-x
Patent ID: ┄
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