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ID: ALA1134859
Journal: Bioorg Med Chem Lett
Title: Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.
Authors: Pitts WJ, Guo J, Dhar TG, Shen Z, Gu HH, Watterson SH, Bednarz MS, Chen BC, Barrish JC, Bassolino D, Cheney D, Fleener CA, Rouleau KA, Hollenbaugh DL, Iwanowicz EJ.
Abstract: A series of novel triazine-based small molecule inhibitors (IV) of inosine monophosphate dehydrogenase was prepared. The synthesis and the structure-activity relationships (SAR) derived from in vitro studies are described.
CiteXplore: 12127522