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ID: ALA1134863
Journal: Bioorg Med Chem Lett
Title: Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols.
Authors: Nicholas GM, Li R, MacMillan JB, Molinski TF.
Abstract: The in vitro antifungal activity of a series of alpha,omega-bifunctionalized aminoalcohols against Candida glabrata was measured. The dimeric bi-functionalized lipids exhibited activity about approximately 10-fold higher higher than D-sphingosine, which is a larger factor than expected from the simple additive effects of vicinal aminoalcohols groups.
CiteXplore: 12127527