Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis.

ID: ALA1134869

Journal: Bioorg Med Chem Lett

Title: Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis.

Authors: Willoughby CA, Bull HG, Garcia-Calvo M, Jiang J, Chapman KT, Thornberry NA.

Abstract: A novel class of small molecule human granzyme B inhibitors is reported. Compound 20 has a K(i) of 7 nM against human granzyme B and blocks CTL mediated apoptosis with an IC(50) of 3 micromolar.

CiteXplore: 12127536

DOI: 10.1016/s0960-894x(02)00363-3

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