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ID: ALA1134870
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of novel inhibitors of gelatinase B.
Authors: Wang X, Choe Y, Craik CS, Ellman JA.
Abstract: A new method was developed to identify nonpeptidic metalloproteinase inhibitors with novel zinc binding groups. Application of this method to matrix metalloproteinase-9 resulted in the identification of aminomethyl benzimidazole analogue 7a with an IC(50)=13 microM.
CiteXplore: 12127537