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ID: ALA1134892
Journal: Bioorg Med Chem Lett
Title: Novel inhibitors of plasminogen activator inhibitor-1: development of new templates from diketopiperazines.
Authors: Wang S, Golec J, Miller W, Milutinovic S, Folkes A, Williams S, Brooks T, Hardman K, Charlton P, Wren S, Spencer J.
Abstract: Several isoquinoline-based templates were identified from the studies of the conformational effects of the diketopiperazine structures for PAI-1 inhibition. Moderate to good activity was retained with the elimination of unattractive characteristics in the diketopiperazine template.
CiteXplore: 12161135