Document Report Card
Basic Information
ID: ALA1134896
Journal: Bioorg Med Chem Lett
Title: Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin.
Authors: Bhattacharya G, Salem MM, Werbovetz KA.
Abstract: Novel dinitroaniline sulfonamides based on the herbicide oryzalin 3 were synthesized and evaluated for activity against the parasitic protozoan Leishmania donovani and against leishmanial tubulin, the putative antiparasitic target of oryzalin. A subset of these compounds possess more activity against both Leishmania and the target protein in vitro. Compound 20 displays improved potency against leishmanial tubulin and is 13.4-fold more active against L. donovani axenic amastigotes than oryzalin.
CiteXplore: 12161141