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ID: ALA1134897
Journal: Bioorg Med Chem Lett
Title: C-3 Amido-indole cannabinoid receptor modulators.
Authors: Hynes J, Leftheris K, Wu H, Pandit C, Chen P, Norris DJ, Chen BC, Zhao R, Kiener PA, Chen X, Turk LA, Patil-Koota V, Gillooly KM, Shuster DJ, McIntyre KW.
Abstract: C-3 Amido-indoles were found to selectively bind to the CB2 receptor. SAR studies led to optimized compounds with excellent in vivo potency against LPS induced TNF-alpha release in murine models of cytokine production.
CiteXplore: 12161142