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ID: ALA1134914
Journal: Bioorg Med Chem Lett
Title: Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.
Authors: Linton SD, Karanewsky DS, Ternansky RJ, Wu JC, Pham B, Kodandapani L, Smidt R, Diaz JL, Fritz LC, Tomaselli KJ.
Abstract: Parallel synthesis was used to explore the SAR of a peptidomimetic caspase inhibitor. The most potent compound had nanomolar activity against caspases 1, 3, 6, 7, and 8.
CiteXplore: 12270185