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Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization.

Basic Information

ID: ALA1134915

Journal: Bioorg Med Chem Lett

Title: Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization.

Authors: Linton SD, Karanewsky DS, Ternansky RJ, Chen N, Guo X, Jahangiri KG, Kalish VJ, Meduna SP, Robinson ED, Ullman BR, Wu JC, Pham B, Kodandapani L, Smidt R, Diaz JL, Fritz LC, von Krosigk U, Roggo S, Schmitz A, Tomaselli KJ.

Abstract: A new structural class of broad spectrum caspase inhibitors was optimized for its activity against caspases 1, 3, 6, 7, and 8. The most potent compound had low nanomolar broad spectrum activity, in particular, single digit nanomolar inhibitory activity against caspase 8.

CiteXplore: 12270186

DOI: 10.1016/s0960-894x(02)00630-3

Patent ID: