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ID: ALA1134917
Journal: Bioorg Med Chem Lett
Title: Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors.
Authors: Berger D, Dutia M, Powell D, Wissner A, DeMorin F, Raifeld Y, Weber J, Boschelli F.
Abstract: A series of substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles has been prepared as Src kinase inhibitors. Optimal activity is observed with compounds that have basic amines attached via the para position of the 7-phenyl ring, and a hydrogen atom at the C-6 position. The best compounds are low nanomolar inhibitors of Src kinase, and have potent activity against Src-transformed fibroblast cells.
CiteXplore: 12270190