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ID: ALA1134964
Journal: Bioorg Med Chem Lett
Title: Heterocyclic benzazole derivatives with antimycobacterial in vitro activity.
Authors: Kocí J, Klimesová V, Waisser K, Kaustová J, Dahse HM, Möllmann U.
Abstract: The series of 2-benzylsulfanyl derivatives of benzoxazole and benzothiazole were synthesized, evaluated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis and non-tuberculous mycobacteria, and the activity expressed as the minimum inhibitory concentration (MIC) in micromol/L. The substances bearing two nitro groups (4e, 4f, 5e, 5f) or a thioamide group (4i, 4j, 5i, 5j) exhibited appreciable activity particularly against non-tuberculous strains. The most active compounds were subjected to the toxicity assay and were evaluated as moderately cytotoxic.
CiteXplore: 12392731