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ID: ALA1134971
Journal: Bioorg Med Chem Lett
Title: Novel human histamine H(3) receptor antagonists.
Authors: Shah C, McAtee L, Breitenbucher JG, Rudolph D, Li X, Lovenberg TW, Mazur C, Wilson SJ, Carruthers NI.
Abstract: High throughput screening, using the recombinant human H(3) receptor, was used to identify novel histamine H(3) receptor antagonists. Evaluation of the lead compounds ultimately afforded potent, selective, orally bioavailable compounds (e.g., 38) with favorable blood-brain barrier penetration.
CiteXplore: 12392739