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ID: ALA1134975
Journal: Bioorg Med Chem Lett
Title: 3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: a potent and highly selective inducible nitric oxide synthase inhibitor.
Authors: Tsymbalov S, Hagen TJ, Moore WM, Jerome GM, Connor JR, Manning PT, Pitzele BS, Hallinan EA.
Abstract: (3S,4S,5R)-2-Imino-4-methyl-5-pentyl-3-pyrrolidinol hydrochloride (1) is a potent inducible nitric oxide synthase (i-NOS) inhibitor that has three times the selectivity of its parent, (+)-cis-4-methyl-5-pentylpyrrolidin-2-imine hydrochloride (2).
CiteXplore: 12392746