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ID: ALA1134977
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of ethyl pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease.
Authors: Slater MJ, Andrews DM, Baker G, Bethell SS, Carey S, Chaignot H, Clarke B, Coomber B, Ellis M, Good A, Gray N, Hardy G, Jones P, Mills G, Robinson E.
Abstract: Using a pyrrolidine-5,5-trans-lactam template, we have designed small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. Compound 11a, with an alpha-ethyl P1 substituent and a Boc-valine substituent at the pyrrolidine nitrogen, has an IC(50)=30 microM.
CiteXplore: 12419361