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ID: ALA1135007
Journal: Bioorg Med Chem Lett
Title: Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators.
Authors: Thor M, Beierlein K, Dykes G, Gustavsson AL, Heidrich J, Jendeberg L, Lindqvist B, Pegurier C, Roussel P, Slater M, Svensson S, Sydow-Bäckman M, Thornström U, Uppenberg J.
Abstract: A series of 5-substituted 2-benzoylaminobenzoic acids has been synthesized and assayed for PPARalpha/gamma activity. Both dual activators and selective PPARgamma agonists have been identified. This class of compounds was shown to activate the PPARgamma receptor through interaction with a novel binding site.
CiteXplore: 12443777