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ID: ALA1135027
Journal: Bioorg Med Chem Lett
Title: Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly.
Authors: Kehoe JW, Maly DJ, Verdugo DE, Armstrong JI, Cook BN, Ouyang YB, Moore KL, Ellman JA, Bertozzi CR.
Abstract: Tyrosylprotein sulfotransferases (TPSTs) catalyze the sulfation of tyrosine residues within secreted and membrane-bound proteins. The modification modulates protein-protein interactions in the extracellular environment. Here we use combinatorial target-guided ligand assembly to discover the first known inhibitors of human TPST-2.
CiteXplore: 11814789