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Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor...

Basic Information

ID: ALA1135028

Journal: Bioorg Med Chem Lett

Title: Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor alpha.

Authors: Miyachi H, Nomura M, Tanase T, Suzuki M, Murakami K, Awano K.

Abstract: Optically active phenylpropanoic acid derivatives [(S)-5, and (R)-5] were prepared, and their affinities for peroxisome proliferator-activated receptor (PPAR)alpha and PPAR gamma were evaluated. Binding assay and cell-based reporter assay indicated that the activity of these compounds is enantio-dependent, and resides exclusively on the (S)-isomer.

CiteXplore: 11814790

DOI: 10.1016/s0960-894x(01)00732-6

Patent ID: