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ID: ALA1135046
Journal: Bioorg Med Chem Lett
Title: Synthesis of an alpha-aminophosphonate nucleoside as an inhibitor of S-adenosyl-L-homocysteine hydrolase.
Authors: Steere JA, Sampson PB, Honek JF.
Abstract: A phosphonic acid analogue of S-adenosyl-L-homocysteine was prepared by a novel method and the epimeric mixture separated. Preliminary studies indicate that each epimer causes time-dependent inactivation of S-adenosyl-L-homocysteine hydrolase, however each presented distinct kinetic characteristics.
CiteXplore: 11814819