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ID: ALA1135055
Journal: Bioorg Med Chem Lett
Title: Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.
Authors: Kalgutkar AS, Rowlinson SW, Crews BC, Marnett LJ.
Abstract: This paper describes SAR studies involved in the transformation of the NSAID meclofenamic acid into potent and selective cyclooxygenase-2 (COX-2) inhibitors via neutralization of the carboxylate moiety in this nonselective COX inhibitor.
CiteXplore: 11844663