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ID: ALA1135067
Journal: Bioorg Med Chem Lett
Title: Synthesis and antithrombotic activity of carbolinecarboxyl RGD sequence.
Authors: Lin N, Zhao M, Wang C, Peng S.
Abstract: 3S-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid, RGDS, RGDV, RGDF and their linkers were synthesized. The anti-aggregation and adhesion of platelet indicated that the in vitro activities of the linkers remained at the same level as RGDS, RGDV, and RGDF (p>0.05). The antithrombotic activities in vivo suggested, however, that the potencies of RGDS, RGDV and RGDF were enhanced by the introduction of 3S-1,2,3,4-tetrahydro-beta-carboline-3-carboxyl group into their alpha amino group (p<0.05, 0.01 or 0.001).
CiteXplore: 11844677