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ID: ALA1135080
Journal: Bioorg Med Chem Lett
Title: Pyridazine based inhibitors of p38 MAPK.
Authors: McIntyre CJ, Ponticello GS, Liverton NJ, O'Keefe SJ, O'Neill EA, Pang M, Schwartz CD, Claremon DA.
Abstract: Trisubstituted pyridazines were synthesized and evaluated as in vitro inhibitors of p38MAPK. The most active isomers were those possessing an aryl group alpha and a heteroaryl group beta relative to the nitrogen atom in the 2-position of the central pyridazine. Additionally, substitution in the 6-position of the central pyridazine with a variety of dialkylamino substituents afforded a set of inhibitors having good (p38 IC50 1-20 nM) in vitro activity.
CiteXplore: 11844702