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ID: ALA1135085
Journal: Bioorg Med Chem Lett
Title: Potent P1' biphenylmethyl substituted aggrecanase inhibitors.
Authors: Yao W, Chao M, Wasserman ZR, Liu RQ, Covington MB, Newton R, Christ D, Wexler RR, Decicco CP.
Abstract: A series of cis-1(S)2(R)-amino-2-indanol based compounds with a biphenylmethyl group at the P1' position was found to be potent aggrecanase inhibitors. Both compounds 2j and 2n possessed very high aggrecanase affinity (IC(50)=1.5nM), and showed excellent selectivity over MMP-1 and MMP-9, with moderate selectivity against MMP-2.
CiteXplore: 11738583