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ID: ALA1135129
Journal: Bioorg Med Chem Lett
Title: N-Tetrahydrofuroyl-(L)-phenylalanine derivatives as potent VLA-4 antagonists.
Authors: Yang GX, Chang LL, Truong Q, Doherty GA, Magriotis PA, de Laszlo SE, Li B, MacCoss M, Kidambi U, Egger LA, McCauley E, Van Riper G, Mumford RA, Schmidt JA, Hagmann WK.
Abstract: Given the proposed involvement of VLA-4 in inflammatory processes, a program to identify orally active VLA-4 antagonists was initiated. Herein, we report the discovery of a N-tetrahydrofuroyl-(L)-phenylalanine derivative (17) and related analogues as potent VLA-4 antagonists with good oral bioavailability.
CiteXplore: 12031328