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ID: ALA1135138
Journal: Bioorg Med Chem Lett
Title: 2-Aminothiazoles: a new class of agonist allosteric enhancers of A(1) adenosine receptors.
Authors: Chordia MD, Murphree LJ, Macdonald TL, Linden J, Olsson RA.
Abstract: This report describes the synthesis and structure-activity relationships of a new class of A(1) adenosine receptor agonist allosteric enhancers, 2-aminothiazolium salts. The EC(50) of compounds 6a, 6b, 7, and 8 were 0.3, 4.5, 3.8, and 1.2 microM, substantially lower than that of the 'Gold Standard' 2-amino-3-benzoyl thiophene (PD 81,723), which has an EC(50) of 38 microM.
CiteXplore: 12039562