Document Report Card

Basic Information

ID: ALA1135149

Journal: Bioorg Med Chem Lett

Title: Syntheses of depsipeptide analogues of the insect neuropeptide proctolin.

Authors: Scherkenbeck J, Plant A, Stieber F, Lösel P, Dyker H.

Abstract: Four depsipeptide analogues of the insect neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) have been prepared, containing a single ester linkage between Arg(1) and Tyr(2), Tyr(2) and Leu(3), and between Pro(4) and Thr(5), respectively. A didepsipentapeptide containing an ester linkage between Tyr(2) and Leu(3) and between Pro(4) and Thr(5), has also been prepared. The depsipeptide 4 is the first example of a backbone-modified proctolin analogue which shows full myotropic activity.

CiteXplore: 12039577

DOI: 10.1016/s0960-894x(02)00214-7