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ID: ALA1135149
Journal: Bioorg Med Chem Lett
Title: Syntheses of depsipeptide analogues of the insect neuropeptide proctolin.
Authors: Scherkenbeck J, Plant A, Stieber F, Lösel P, Dyker H.
Abstract: Four depsipeptide analogues of the insect neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) have been prepared, containing a single ester linkage between Arg(1) and Tyr(2), Tyr(2) and Leu(3), and between Pro(4) and Thr(5), respectively. A didepsipentapeptide containing an ester linkage between Tyr(2) and Leu(3) and between Pro(4) and Thr(5), has also been prepared. The depsipeptide 4 is the first example of a backbone-modified proctolin analogue which shows full myotropic activity.
CiteXplore: 12039577