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ID: ALA1135158
Journal: Bioorg Med Chem Lett
Title: Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck.
Authors: Calderwood DJ, Johnston DN, Munschauer R, Rafferty P.
Abstract: A series of pyrrolo[2,3-d]pyrimidines was synthesized and evaluated as inhibitors of Lck. Lck accommodates a diverse set of substituents at N-7. Altering the substituent at N-7 provided compound 13, an orally available lck inhibitor which inhibited TCR mediated IL-2 production after oral dosing.
CiteXplore: 12039590