New ketosteroids from the red alga Hypnea musciformis.

ID: ALA1135164

Journal: Bioorg Med Chem Lett

Title: New ketosteroids from the red alga Hypnea musciformis.

Authors: Bultel-Poncé V, Etahiri S, Guyot M.

Abstract: The dichloromethane/methanol extract from the red alga Hypnea musciformis exhibited PPE elastase inhibition. A diketosteroid, the 20-hydroxy-5alpha-cholest-22-ene-3,6-dione was responsible for this activity. Two new steroids were isolated, 2 was assigned as the 6alpha-hydroxy-cholest-4-ene-3-one and 3 as the 6alpha-hydroxy-cholest-4,22-diene-3-one. The structures were assigned mainly on the basis of 1H and 13C NMR experiments.

CiteXplore: 12067544

DOI: 10.1016/s0960-894x(02)00295-0

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