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ID: ALA1135194
Journal: Bioorg Med Chem Lett
Title: Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles.
Authors: Boschelli DH, Wang DY, Ye F, Yamashita A, Zhang N, Powell D, Weber J, Boschelli F.
Abstract: Based on a screening lead from a yeast-based assay to identify Src family kinase inhibitors, a series of 4-anilino-7-thienyl-3-quinolinecarbonitriles was prepared. When the thiophene ring was substituted with a water-solubilizing group in a 2,5-, 3,5- or 2,4-pattern, potent inhibition of Src kinase activity was observed.
CiteXplore: 12113830