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ID: ALA1135205
Journal: Bioorg Med Chem Lett
Title: Solid-phase synthesis and investigation of benzofurans as selective estrogen receptor modulators.
Authors: Smith RA, Chen J, Mader MM, Muegge I, Moehler U, Katti S, Marrero D, Stirtan WG, Weaver DR, Xiao H, Carley W.
Abstract: A library of benzofurans was prepared by solid-phase synthesis methods, and several analogues were identified as potent ligands for the estrogen receptors ER-alpha and ER-beta, with some compounds having selectivity for ER-alpha. Analogues designed to more closely mimic Raloxifene were less effective. Certain benzofurans were effective in a bone pit assay, but were characterized as agonists in a MCF-7 breast tumor cell proliferation assay.
CiteXplore: 12270167