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ID: ALA1135213

Journal: Bioorg Med Chem Lett

Title: New indene-derivatives with anti-proliferative properties.

Authors: Karaguni IM, Glüsenkamp KH, Langerak A, Geisen C, Ullrich V, Winde G, Möröy T, Müller O.

Abstract: Metabolites of the non-steroidal anti-inflammatory drug Sulindac inhibit cell proliferation by affecting several intracellular signaling pathways including the tumorigenic Ras/Raf/MAPK pathway. Here, we report the synthesis of eight new indene derivatives derived from the Sulindac structure, and present data on their anti-proliferative properties and their effects on the p21ras protein.

CiteXplore: 11844707

DOI: 10.1016/s0960-894x(01)00839-3