Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors.

ID: ALA1135224

Journal: Bioorg Med Chem Lett

Title: Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors.

Authors: Goel A, Mazur SJ, Fattah RJ, Hartman TL, Turpin JA, Huang M, Rice WG, Appella E, Inman JK.

Abstract: The HIV-1 nucleocapsid protein NCp7, which contains two highly conserved zinc fingers, is being used as a novel target for AIDS therapy due to its pivotal role in viral replication and its mutationally intolerant nature. Herein we report a new class of NCp7 inhibitors that possess good antiviral activity with low cellular toxicity.

CiteXplore: 11858998

DOI: 10.1016/s0960-894x(02)00007-0

Patent ID: ┄