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ID: ALA1135255
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and bioactivity evaluation of tribactam beta lactamase inhibitors.
Authors: Copar A, Prevec T, Anzic B, Mesar T, Selic L, Vilar M, Solmajer T.
Abstract: Known carbapenem compounds with inhibitory effect towards beta-lactamase enzymes are formed from bicyclical beta lactam structural scaffolds. On the basis of results from theoretical computational methods and molecular modelling we have designed and developed a synthetic route towards novel, biologically active tricyclic derivatives of carbapenems.
CiteXplore: 11959006