Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists.

ID: ALA1135271

Journal: Bioorg Med Chem Lett

Title: Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists.

Authors: Wang Y, Chackalamannil S, Hu Z, McKittrick BA, Greenlee W, Ruperto V, Duffy RA, Lachowicz JE.

Abstract: We have discovered highly potent, selective sulfide M(2) receptor antagonists with low molecular weight and different structural features compared with our phase I clinical candidate Sch 211803. Analogue 30 showed superior M(2) receptor selectivity profile over Sch 211803. More importantly, this study provided new leads for the discovery of M(2) receptor antagonists as potential drug candidates.

CiteXplore: 11909724

DOI: 10.1016/s0960-894x(02)00096-3

Patent ID: ┄